Hesperidin for prophylaxis and treatment of diseases of the central nervous system, in particular Alzheimer's and Parkinson's diseases, for therapy after stroke as well as for chronic pain.

摘要

The use of hesperidin (I) or its salts in the production of medicaments for the prophylaxis and treatment of Alzheimer's disease or Parkinson's disease. ACTIVITY : Neuroprotective; Nootropic; Antiparkinsonian. MECHANISM OF ACTION : Cholinergic, noradrenergic and dopaminergic neurotransmission mediator. In tele-stereo-EEG tests in rats (see Eur. J. Med. Res. (2003) 8; 1990-207), (I) at intraperitoneal doses of 80 or 160 mg/kg caused significant, dose-dependent changes in electrical activity in the brain, with a stable pattern over a long period. At 160 mg/kg (I) caused a reduction in the delta wave (cholinergic), tau wave (noradrenergic) and alpha 2 wave (dopaminergic) frequencies, starting within the first hour and maintained during the full 5 hours of the test. The pattern correlated well with those obtained with known drugs for treating neurodegenerative drugs, e.g. tacrin, piracetam or memantine.