MAMMALIAN HYPOTHALAMIC NUTRIENT MODULATION OF GLUCOSE METABOLISM

摘要

Provided are methods of reducing glucose production in a mammal, methods of reducing food intake in a mammal, methods of inhibiting gluconeogenesis in the liver of a mammal, methods of reducing peripheral blood glucose levels in a mammal, methods of decreasing serum triglyceride levels in a mammal, and methods of decreasing very low density lipoprotein (VLDL) levels in a mammal. The methods comprise administering a compound to the mammal, where administering the compound to the mammal causes an increase in tricarboxylic acid (TCA) cycle flux through acetyl-CoA in the hypothalamus of the mammal. Also provided are methods of increasing glucose production in a mammal and methods of increasing food intake in a mammal. The methods comprise administering a compound to the mammal that causes a decrease in tricarboxylic acid (TCA) cycle flux through acetyl-CoA in the hypothalamus of the mammal and an increase in food intake in the mammal. Additionally provided are methods of decreasing very low density lipoprotein (VLDL) levels in a mammal and decreasing serum triglyceride levels in a mammal. The methods comprise increasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus of the mammal in an amount effective to reduce VLDL or triglyceride levels in the mammal.