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Use of trifunctionel antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
Use of trifunctionel antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
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机译:使用三功能抗体降低同种异体抗肿瘤细胞治疗中GvHD的风险
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摘要
The present invention refers to the use of allogenic effector cells together with trifunctional bispecific or trispecific antibodies or a combination thereof having the following properties:a) binding to a T cellb) binding to at least one antigen on a tumor cellc) binding via their Fc portion in the case of trifunctional bispecific antibodies or via third specificity in the case of trispecific antibodies to Fc receptor positive cellssaid antibodies redirecting the allogenic cells away from host tissues in order to substantially reduce or avoid a graft versus host disease for the manufacture of a medicament for treating tumor growth and metastasis in a mammal.
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