Compositions comprising (ant)agonists of oncostatin M (OSM), IL-31 and IFN-gamma for modulating keratinocyte migration and functions via a receptor containing OSMRbeta as a subunit, and applications thereof.

摘要

The present invention relates to the field of epidermal repair. More particularly, the invention concerns the use of a molecule able to act on a heteromeric receptor comprising OSMRβ as a subunit, by inhibiting or activating said subunit, for the preparation of a composition for modulating in vitro and/or in vivo keratinocyte migration and/or the expression of inflammatory factors by the keratinocytes. In particular, the invention concerns the use of OSM and/or IL-31, or antagonists thereof, for the preparation of cosmetic or dermatologic compositions. Methods for obtaining in vitro or animal models of skin inflammation diseases are also disclosed. These models can be used for screening molecules to find new drugs to prevent or treat psoriasis and other dermatitis.