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REVERSING, POSTPONING OR PREVENTING THE OCCURRENCE OF GTN TOLERANCE AND/OR GENERATION OF REACTIVE OXYGEN SPECIES FROM MITOCHONDRIA
REVERSING, POSTPONING OR PREVENTING THE OCCURRENCE OF GTN TOLERANCE AND/OR GENERATION OF REACTIVE OXYGEN SPECIES FROM MITOCHONDRIA
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机译:逆转,推迟或预防线粒体的GTN耐受性和/或生成活性氧物种
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摘要
A patient in need of nitroglycerin therapy is treated with nitroglycerin and agent that prevents inhibition of or reverses inhibition of mtALDH and/or the generation of reactive oxygen species from mitochondria, e.g., a mitochondrial antioxidant which is not a reducing agent or a dithiol, e.g., ebselen or uric acid. Nitroglycerin dosage can be regulated and inhibiting agent dosage can be regulated and tolerance postponed by monitoring blood level of active mtALDH and dosing in response to determined level of active mtALDH.
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