ETHYL ??2 ???? ??METHOXYIMINO ?? ??2-?? - ??1E ??-1- ??3- ??TRIFLUOROMETHYL ??PHENYL ??-ETHYLIDENDE- AMINO ??OXY ??METHYL ??PHENYL ??ACETATE OR ETHYL ??2 ??- ??METHOXYIMINO ?? 2- ?? ??- ?? ??1E ??-4-CHLOROPHENYL ?? ??CYCLOPROPYL ??-METHYLENE ??AMINO- OXY ??METHYL ??PHENYL ?? ACETATE

摘要

Preparation of iminoacetic acid derivatives of formula (I) comprises: (a) reacting a tert-amine of formula (II) with LiR7 in an aprotic solvent; (b) treating the resulting complex with Y1CO-COY1 (IV) to form a phenylglyoxylate of formula (V); (c) sequential reaction of this with O-methylhydroxylamine (A) (or with hydroxylamine and then methylation or mono- or di-fluoromethylation) and a chloroformate ester. X = inert substituent; m = 0-4; R3 = H, Me or mono- or di-fluoromethyl; Y = OR4, N(R5)2 or NMe-OMe; R4, R5 = H or 1-8C alkyl; or N(R5)2 = 5-6 membered, optionally substituted, ring; R1, R2 = 1-6C alkyl, alkenyl or alkoxyalkyl, or 3-6C cycloalkyl; or NR1R2 = optionally substituted 6-7 membered ring which may include an additional nitrogen; Y1 = OR4', N(R6)2, NMeOMe, imidazolyl or halo; R4', R6 = 1-8C alkyl; or N(R6)2 = optionally substituted 5- or 6-membered ring; R7 = anionic organic residue; provided that when Y1 is imidazolyl or halo, these are exchanged by Y (sic).