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POLYMORPHISMS OF CHROMOSOME 9 IMPLICATED IN PREMATURE CANITIES

机译:早熟人群中暗示的染色体9的多态性

摘要

The invention relates to the use of at least one of the 4 SNP markers rs306534, rs3739902, rs575916 and rs365297 for carrying out a diagnosis, a process for diagnosing a predisposition to premature canities, the use of a means for determining the alleles of the 4 markers with a view to a diagnosis and a kit for the diagnosis, a process for the diagnosis of a predisposition to premature canities based on the haplotype defined by the markers rs3739902, rs2583805 and rs377090 and the use of at least one polynucleotide fragment comprising at least 18 consecutive nucleotides, the sequence of which corresponds to all or part of the region in a non-human mammal homologous to that of the human chromosome 9 defined by the SNP markers rs306534 and rs365297 for the diagnosis of a predisposition to premature canities in said mammal.
机译:本发明涉及4种SNP标志物rs306534,rs3739902,rs575916和rs365297中的至少一种在进行诊断中的用途,诊断早产易感性的方法,确定4种等位基因的手段的用途。用于诊断的标记和用于诊断的试剂盒,用于基于标记rs3739902,rs2583805和rs377090定义的单倍型诊断早产易感性的方法以及至少一种包含至少一个多核苷酸片段的多核苷酸的用途18个连续核苷酸,其序列对应于与SNP标记rs306534和rs365297定义的人类染色体9同源的非人类哺乳动物的全部或部分区域,用于诊断所述哺乳动物中早产易感性。

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