Crystal structure of an Aurora-B/INCENP complex

摘要

The present invention provides crystalline molecules or molecular complexes which comprise binding sites of Aurora-B-like polypeptides. The invention also relates to the structural coordinates of Aurora-B/INCENP complexes and methods of using computational means to evaluate the ability of compounds to bind to the molecule or molecular complexes. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen and design compounds, including inhibitory compounds that bind to Aurora-B-like polypeptides.