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ISOLATION OF BONE MARROW FRACTION RICH IN CONNECTIVE TISSUE GROWTH COMPONENTS AND THE USE THEREOF TO PROMOTE CONNECTIVE TISSUE FORMATION
ISOLATION OF BONE MARROW FRACTION RICH IN CONNECTIVE TISSUE GROWTH COMPONENTS AND THE USE THEREOF TO PROMOTE CONNECTIVE TISSUE FORMATION
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机译:结缔组织生长成分中富含骨的骨髓碎片的分离及其用于促进结缔组织形成的作用
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摘要
A bone marrow isolate rich in one or more connective tissue growth components, methods of forming the isolate, and methods of promoting connective tissue growth using the isolate are described. A biological sample comprising bone marrow is centrifuged to separate the sample into fractions including a fraction rich in connective tissue growth components. The fraction rich in connective tissue growth components is Then isolated from the separated sample. The isolate can be used directly or combined with a carrier and implanted into a patient at a tissue (e.g., bone) defect site. The biological sample can comprise bone marrow and whole blood. The isolate can be modified (e.g., by transfection with a nucleic acid encoding an osteoinductive polypeptide operably linked to a promoter) prior to application to the tissue defect site. The isolate can be made and applied to the tissue defect site in a single procedure (i.e., intraoperatively).
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