PEPTIDE ORIGINATED FROM POLO-LIKE KINASE C-TERMINAL AND THEIR USE IN SCREENING OF PLK1 TARGET PROTEINS

摘要

invention Plk1 (Polo-like kinase) of the C-terminal amino acid sequence derived from the inclusion of It relates to a peptide and a screening method of Plk1 target protein using the same. Specifically, the 410 to 439th amino acid sequence located at the C- terminal of Plk1 (Polo-like kinase) plays an important function across similar cleavable groups of the cell cycle It relates to a peptide and a peptide containing the organelles of the core body (centrosome) and screening methods using as an intermediate (midbody) or Plk1 molecule that can specifically recognize the target protein marker (marker). A peptide of the present invention is combined with the target protein easy least motif (motif), cells useful for the screening of proteins that bind and Plk1 and Plk1 plays an important role in the growth process of the cancer cells as well as the proliferation of normal cells to a target period can be efficiently used for screening of controlled substances, diagnostic and Plk1 in cancer tissues may be used for a variety of anti-cancer agents or drugs useful in the navigation system of the target.