INTERFERON-GAMMA INHIBITING HEPATITIS B VIRUS-INDUCED NF-KB ACTIVATION

摘要

A novel use of an interferon-gamma for inhibiting NF(nuclear factor)-kappaB activation induced by the hepatitis B virus is provided to inhibit or prevent liver disease caused by NF-kappaB-including liver cancer and hepatitis by inhibiting activation of NF-kappaB and migration of kinase suppressing NF-kappaB into the nucleus in a cell. The interferon-gamma is useful for inhibiting or preventing liver disease associated with NF-kappaB. A drug capable of inhibiting or preventing liver disease associated with NF-kappaB is screened by verifying the migration of kinase suppressing NF-kappaB into the nucleus in a cell.