NEUROPEPTIDE HAVING RELAXING ACTIVITY OF SMOOTH MUSCLE

摘要

A neuropeptide having relaxing activity of smooth muscle is provided to improve smooth muscle-relaxing activity, and reduce the number of amino acids, so that the neuropeptide is mass produced. The neuropeptide having relaxing activity of smooth muscle has the amino acid sequence of SEQ ID NO:2, wherein the C-terminal is carboxylated or amidated and the amine group of N-terminal is substituted by alkyl or acetyl group; the amino acid sequence is L-type and/or D-type. A nucleic acid containing DNA or RNA encodes the neuropeptide of SEQ ID NO:2. A recombinant vector contains the nucleic acid. The neuropeptide having relaxing activity of smooth muscle is produced by transforming bacterium, yeast or fungus with the recombinant vector, and culturing the transformed microorganism. A composition is used for improving at least one symptom selected from bronchial asthma, hypertension, diuresis and impotence.