Method for Identifying Anti-Cancer Material by Using the specific Enzyme­Substrate Relationship between RET/PTC and STAT3

摘要

PURPOSE: A method for identifying an anti-cancer material by using the specific enzyme-substrate relationship between RET/PTC and STAT3 is provided, thereby easily measuring the activity of RET/PTC, and screening the RET/PTC inhibiting materials, so that it can be useful for development of anticancer materials. CONSTITUTION: The method for measuring the activity of RET/PCT comprises using the specific enzyme-substrate relationship between RET/PTC and STAT3(signal transducer and activator of transcription-3), wherein the RET/PTC proteins increase phosphorylation of tyrosine residue of STAT3 in vivo and in vitro; and the RET/PTC proteins are RET/PTC1 and RET/PTC3. The method for identifying an anti-cancer material comprises using the specific enzyme-substrate relationship between RET/PTC and STAT3(signal transducer and activator of transcription-3).