ORAL MICRO-EMULSION COMPOSITION COMPRISING BIPHENYLDIMETHYLDICARBOXYLATE, AND CARDUUS MARIANUS EXTRACT OR SILYBIN ISOLATED THEREFROM

摘要

A microemulsion composition comprising biphenyldimethyldicarboxylate (BDD) and silybin or a derivative thereof, or a iCarduus marianus/i extract containing silybin and derivatives thereof, as active ingredients; a co-surfactant; a surfactant; and an oil provides a synergistic therapeutic effect for liver diseases due to the complementary work of the two kinds of active ingredients having different working mechanisms without any adverse side effect or an antagonism, and high iin vivo/i bioavailabilities of both of the active ingredients, when orally administered.