Analytic method for hazard of ventricular tachyarrhythmia inducing pharmaceutics by detecting cardiac action potential

摘要

The present invention relates to a method for analyzing cardiac arrhythmia induced risk of a drug, and more specifically, 1) separating a heart from an animal; 2) separating the myocardial tissue from the heart separated in step 1; 3) immersing the myocardial tissue separated in step 2 in a chamber containing a constant water level (Normal Tyrode) solution, and prevents the solution from swelling; 4) fixing the myocardial tissue in the chamber in step 3 to the bottom of the silicon-coated plate; And 5) measuring the action potential after the drug is treated in the fixed myocardial tissue of step 4, and the cardiac arrhythmia induced risk analysis method. The analytical method of the present invention can be usefully used to test the efficacy of drugs that may affect heart attacks and the like.