Use of Cyclophilin As Antioxidant and Prevention of Cyclosporin A-induced Toxicity in Cell Transplantation by Overexpression of Cyclophilin

摘要

The present invention relates to an antioxidant comprising the cycloalkyl pilrin protein having PPIase activity. In addition, the present invention is characterized in that it comprises a recombinant expression vector expressing a cycloalkyl pilrin protein having the PPIase activity of an amount effective to reduce the toxicity caused by the immunosuppressive agent cyclosporin A or analogs thereof in transplanted cells, transplanted cells the cycloalkyl in by inducing over-expression of protein pilrin relates to a pharmaceutical composition for preventing toxicity caused by cyclosporin a or analogs thereof. The invention also relates to a method for producing transplant cells and resistant to expression of cycloalkyl are derived pilrin protein cyclosporin A or analogs thereof having a PPIase activity. ; Cell transplantation, cyclosporine A, cytotoxicity, expression of muscle differentiation, cycloalkyl pilrin proteins, antioxidants, PPIase activity