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Pyridazinyl-piperazines and their use as histamine H3 receptor ligands H3
Pyridazinyl-piperazines and their use as histamine H3 receptor ligands H3
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机译:哒嗪基-哌嗪及其作为组胺H3受体配体H3的用途
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摘要
The present invention relates, inter alia, to novel piperazines of the following formula: to the use of these compounds in the preparation of pharmaceutical compositions, to pharmaceutical compositions comprising the compounds, and to methods of treatment employing these compounds or compositions. The compounds show a high and selective binding affinity for the histamine H3 receptor, indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases or disorders related to the histamine H3 receptor.
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