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DIMERIC DERIVATIVE OF NETROPSIN - 15-LYS-BIS-NETROPSIN AND COMBINATIONS BASED ON THEREOF POSSESSING ANTI-HERPETIC ACTIVITY
DIMERIC DERIVATIVE OF NETROPSIN - 15-LYS-BIS-NETROPSIN AND COMBINATIONS BASED ON THEREOF POSSESSING ANTI-HERPETIC ACTIVITY
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机译:中性神经肽-15-LYS-BIS-内啡肽的二元衍生物及其基于抗-抗肝炎活性的组合
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FIELD: organic chemistry, amino acids, virology.;SUBSTANCE: invention relates to a new compound representing dimeric derivative of netropsin, namely, 15-Lys-bis-netropsin: 4-[4-[4-[4-[α,ω-bis-[α,ω-bis-(α,ω)-dilysyllysyl)lysyl]lysyl]glycylglycyl]amino-1-pr-opylpyrrol-2-carboxamido]-1-propylpyrrol-2-carbonyl]glycylglycylglycylamino]-1-propylpyrrol-2-carboxamido]-2-(3-dimethylaminopropylaminocarbonyl)-1-pr-opylpyrrole trifluoroacetate possessing an anti-viral activity and its combinations with modified nucleosides or phosphonoacetic/phosphonoformic acid also. Represented combinations provides selectivity of anti-herpetic effect and to enhance anti-herpetic effect significantly as compared with each separately taken combining antiviral compounds.;EFFECT: improved and valuable antiviral activity of derivative.;3 cl, 3 tbl, 4 ex
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