METHOD FOR PREDICTING THE DEVELOPMENT OF TOXIC HEPATITIS AT CHEMOTHERAPY OF MULTIPLE MYELOMA

摘要

FIELD: medicine, hematology.;SUBSTANCE: the present innovation deals with isolating DNA out of lymphocytes of peripheral venous blood due to phenol-chloroform extraction, carrying out the procedure of genotyping polymorphism of promoter area of gene CYP1A1 in site - Ile 462 Val due to polymerase chain reaction of DNA synthesis and subsequent restriction. At detecting genotype Ile-Val one should predict high risk for the development of toxic medicinal hepatitis.;EFFECT: higher accuracy of prediction.;1 tbl