Human proinsulin derivative, coding dna, dna expression vector containing, with this a transformed microorganism and use of this human proinsulin derivative

摘要

Human proinsulin derivative of formula (i): B - chain - z - a - chain (i)wherein:the a - and (b - chains in each case of human insulin chains are;Z is a peptide of the formula # # str1 # # u - u - x - p - j - (x ′) n - u - u is;U is a arginine - or lysine residue;X and x '', independently of one another, an amino acid residue, and (x ′) nn different or the same amino acid residues can be;P is a proline radical is;J a glycine -, arginine - or lysine residue; andn is 0 or an integer from 1 to 5 is.