Biomaterial with a modular coating system for use in medical products with direct blood contact

摘要

Biomaterial with a modular coating system for use in medical products with direct blood contact comprising• a synthetic blood low inhibitor layer arrangement, which via• a flexible spacer layer is connected with the biomaterial surface,• the binding of the spacer layer with the biomaterial surface is formed and that the covalently• Blood fig. 1 is smaller than that of an inhibitor layer of a substance with the structure a - b - c is formed,A is an amidino - or guanidino - group andB - an alpha, beta -, para - bi - substituted phenyl ring or an alkyl chain, andC. an amine - (nh -), thiol - (s -), alcohol - (o -) or a carboxylic acid group (co -), and that• the spacer layer a structure of the form f - g - h,F an amine - (nh -), thiol - (s -), alcohol - (o -) or carboxylic acid group (co -) is,G is an alkyl chain (ch₂)_n with n = 1 to 14 or an oligo - or polyethylene glycol chain in the molecular weight range of from of 200 to 10.000 g / mol andH an amine - (nh -), thiol - (s-),..