Pharmaceutical composition containing phospholipid, sterol and negative charge carrier, useful in human or veterinary medicine for treating e.g. arthropod, protozoal and bacterial infections or tumors

摘要

Pharmaceutical composition (A) comprises (a) a phospholipid (A1); (b) cholesterol, 7-beta -hydroxycholesterol and/or a beta -sitosterol (A2); and (c) a negative charge carrier (A3). Pharmaceutical composition (A) comprises: (a) a phospholipid (A1) of formulae R 1O-PO 2 --O(CH 2) nN +R 2R 3R 4 (I), cyclic phosphate of formula (II), R 1OCH 2CH 2OP (III), R 1OCH 2CH(OP)(CH 2) xMe (IV), R 21OCH 2CH(OR 22)CH 2OP (V), R 31OCH 2C[((CH 2) zH)(CH 2) yH]CH 2OP (VI) or R 41OCH 2C(OH)(Me)CH 2OP (VII); (b) cholesterol, 7beta -hydroxycholesterol and/or a beta -sitosterol (A2); and (c) a negative charge carrier (A3), i.e. a 16-36C carboxylic acid, preferably saturated or (poly)unsaturated, especially with cis-double bonds; a bile acid; an amide of an amino acid with a fatty acid (saturated or (poly)unsaturated) or compound of formula R 51CONHCH 2CH 2OPO 2 --OCH 2CH(OH)CH 2OH Na + (VIII). R 1optionally saturated 15-26C hydrocarbyl; R 2-R 4H, 1-6C alkyl, 3-6C cycloalkyl or 2-5C alkylene, or two of them together form 2-5C alkylene; n : 2-6; R 11, R 21, R 31, R 4115-26C hydrocarbyl, saturated or (poly)unsaturated; R 12, R 13H, 1-6C alkyl or 2-6C hydroxyalkyl; m : 1 or 2; P : -PO 2 --O(CH 2) nN +R 2R 3R 4 or the residue of (II) after removing R 11O; x : 0-4; R 221-6C alkyl; y, z : 0-3, but not both 0; R 5115-25C hydrocarbyl; proviso: in (V) residues R 21, R 22 and P can be distributed as wished over the positions in the glycerol molecule Independent claims are also included for: (1) use of erufosin (not identified) to prepare a composition for treating tumors; (2) (VII) as new compounds; and (3) method for preparing alkylphosphocholine compounds using plant oil, particularly olive oil, as starting material. [Image] ACTIVITY : Acaricide; Cytostatic; Protozoacide; Antibacterial; Ophthalmological; Fungicide. No details of tests for any of these activities are given. MECHANISM OF ACTION : Stimulation of leucopoiesis.