New radioactive metal chelate, complexes useful for nuclear medicine diagnosis and internal radionuclide therapy

摘要

Radioactive metal chelate complexes (I) are new. Radioactive metal chelate complexes of formula (I) are new. A+B' = O, NR 1, S or CHR 1; or A = H and B' = OH, SH, NHR 1or CH 2R 1; R 1= alkyl, aryl, ester or amide, all optionally substituted; D = COOH or a derivative thereof, e.g. ester, amide or peptide; X, Y, Z = substituted pyridines (e.g. substituted with alkyl, halo or NO 2), other heterocycles, e.g. thiophene, furan, thiazole, imidazole or quinoline, or other groups with N, O or S functions; R = alkyl, aryl, ester or amide, all optionally substituted; M* = a radioactive metal; and m, n = 1-5. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : None given. MECHANISM OF ACTION : Internal radionuclide therapy.