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process for the production of optically active 4 - hydroxy - 2 - pyrrolidinone and n - 4 - hydroxy - 2 - replaced: pyrrolidinonen by enzymatic hydroxylation
process for the production of optically active 4 - hydroxy - 2 - pyrrolidinone and n - 4 - hydroxy - 2 - replaced: pyrrolidinonen by enzymatic hydroxylation
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机译:光学活性4-羟基-2-吡咯烷酮和n-4-羟基-2-取代的方法:通过酶促羟基化反应生成吡咯烷酮
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摘要
This invention provides a process for the preparation of optically active 4-hydroxy-2-pyrrolidinone or N-substituted 4-hydroxy-2-pyrrolidinones, wherein an oxygen atom is inserted regio- and stereoselectively into the corresponding non-hydroxylated 2-pyrrolidinones, by using, as a biocatalyst, a microorganism having hydroxylation activity, or a host-organism having the gene(s) necessary for the hydroxylation enzymes derived from the said microorganism, or an enzyme having hydroxylation activity derived from the above microorganisms. The microorganism may be selected from the group consisting of microorganisms that degrade alkanes or cyclic hydrocarbons, microorganisms having alkane hydroxylase(s), or microorganisms that are able to oxidize hydrocarbons.
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