IDENTIFICATION OF MODULATORS OF THE NEUROTRANSMITTER XANTHUREN ACID

摘要

The invention relates to methods and compositions for the selection and development of novel pharmacological agents or novel medicaments having properties or mechanisms of action which are original. The invention specifically describes the characterization and identification of the functional role of several constitutive elements of the central nervous system playing a role in the metabolism or transport of xanthurenic acid (XA) or involved in receiving and/or transducing the signal mediated by this substance. Said targets are new tools for the definition and selection of novel synthetic chemical substances, interfering with said targets and modulating the functions of XA in order to benefit from the pharmacological or medicamentous advantages thereof. The invention can be primarily used to treat neurological or mental pathologies or diseases.