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Combination of an angiotensin II antagonist benzimidazole with manidipine for the treatment of hypertension
Combination of an angiotensin II antagonist benzimidazole with manidipine for the treatment of hypertension
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机译:血管紧张素II拮抗剂苯并咪唑与马尼地平的组合治疗高血压
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摘要
This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula CHEM wherein R1 is H or an optionally substituted hydrocarbon residue; R2 is an optionally esterified carboxyl group; R3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R2; and Y is a bond, -O-, -S(O)m- (wherein m is 0, 1 or 2) or -N(R4)- (wherein R4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity.
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机译:本发明涉及一种用于血管紧张素Ⅱ介导的疾病的药物组合物,该组合物包含具有式的具有血管紧张素Ⅱ拮抗活性的化合物,其中R 1为H或任选取代的烃基。 R 2是任选酯化的羧基; R 3为能够形成阴离子的基团或可转换为阴离子的基团。 X为2个苯环之间的共价键或作为邻接的亚苯基与苯基之间的直链部分的链长为1至2个原子的间隔基; n为1或2;环A是除R 2之外还具有1或2个任选取代基的苯环; Y是键,-O-,-S(O)m-(其中m为0、1或2)或-N(R 4)-(其中R 4为H或任选取代的烷基基团)或其药学上可接受的盐与具有利尿活性的化合物合用。
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