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A method for the production of high virus free thrombin for the preparation of fibrin glue from human plasma - pool
A method for the production of high virus free thrombin for the preparation of fibrin glue from human plasma - pool
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机译:一种高脱毒凝血酶的生产方法,用于从人血浆中制备纤维蛋白胶。
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摘要
This invention relates to a process for preparing biological glue components from a plasma pool which combines high recovery, quality product and viral safety. In first instance, a triple viral inactivated product comprising fibrogen, fibronectin and FXIII is obtained by treating a concentrate thereof first with a viricide solvent/detergent solution, second with viral nanofiltration, and third with heat. The recovery of a good quality product is not compromised by the process of the invention. In second instance, the same steps are reproduced for obtaining a triple viral safe thrombin product. In that case, a known proprietary process has been improved to increase the recovery of active thrombin by about two fold.
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