New phenyl compounds are peroxisome proliferator activated receptor activators useful to treat hyperlipidemia and atherosclerosis

摘要

Phenyl compounds (I) are new. Phenyl compounds of formula (I) are new. A : -(C?=C)- or -(CH2)m-; m : 1-3; Y1H or OH; X1, X2-(CH2)n- or =CH-; R1, R21-8C alkyl or aryl; Z : O, S or -CH2-; and R3-R5H, 1-6C alkyl (optionally substituted). Provided that X1 and X2 do not simultaneously represent =CH-. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Antilipemic; Antiarteriosclerotic. MECHANISM OF ACTION : Peroxisome proliferator activated receptor (PPAR) activator. The agonistic activity of (I) with PPAR was tested. The results showed that 2-[4-(3-hexyl-non-3-en-1-ynyl)phenoxy]-2-methyl-propanoic acid exhibited an EC50 value of 383 nM against PPAR-beta /delta .