FUNCTIONAL ROLE OF ADRENOMEDULLIN (AM) AND GENE-RELATED PRODUCT (PAMP) IN HUMAN PATHOLOGY AND PHYSIOLOGY

摘要

PPROBLEM TO BE SOLVED: To demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse organs and functions as a universal proliferation factor causing neoplastic proliferation; to provide AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions; and to provide methods of diagnosis, treatment and prevention of diseases utilizing compositions comprising the AM peptides and antibodies; and to provide also experimental procedures for use in identifying the role of AM in pancreatic physiology. PSOLUTION: The methods pertaining to rat isolated islets show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, is shown to increase insulin release by fivefold and an effect that is reversed by the addition of synthetic AM. PCOPYRIGHT: (C)2007,JPO&INPIT