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Using methods for determining the structure and function of the molecules of the analysis chip and an analysis chip

机译:使用确定分析芯片和分析芯片的分子的结构和功能的方法

摘要

Analysis chip to investigate the interaction between molecules and functionality of the membrane protein A (2), plurality of nanopores consistent with nanopores of the (28) nanopore substrate of the (8 nanopores with (8) plurality of nanopores suitable support layer stacked substantially planar support layer with a) a (6), nanopore substrate of the (28) on the (6) column (7), and is laminated base layer of the (6) above, it covers plurality of nanopores (8), the bilateral biological effective layer (4) for imaging or measurement results that It is an analysis chip having biological effective layer as possible is made accessible nanopores from, be accommodated functional molecules or non-lipid molecule at least one (4). The present invention, organisms such as the lipid bilayer membrane with high solid stability in a manner that retains the functionality of the entire biological membrane proteins while maintaining the fluidity, were incorporated into the lipid bilayer of the It is intended to provide a support that is structured to enable it to form a kinematic effect layer.
机译:分析芯片以研究分子与膜蛋白A(2),与(8个纳米孔中的(28)个纳米孔底物的(28)个纳米孔底物的纳米孔一致)的多个纳米孔之间的相互作用,其中(8)个多个纳米孔合适的支撑层基本呈平面堆叠a)支撑层(6),(6)柱(7)上的(28)纳米孔基底,以及上面(6)的叠层基础层,它覆盖多个纳米孔(8),两侧用于成像或测量结果的生物有效层(4)是具有尽可能多的生物有效层的分析芯片,其由至少一个(4)的容纳的功能分子或非脂质分子制成可接近的纳米孔。将具有高固体稳定性的生物体如脂质双层膜以保持整个生物膜蛋白的功能性同时保持流动性的方式并入到其双层脂质体中。使其能够形成运动学效果层的结构。

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