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Method for producing oligoglycosaminoglycan, reducing end glucuronic acid type oligochondroitin sulfate, and pharmaceutical composition containing the same
Method for producing oligoglycosaminoglycan, reducing end glucuronic acid type oligochondroitin sulfate, and pharmaceutical composition containing the same
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机译:寡糖氨基聚糖的生产方法,还原型末端葡萄糖醛酸型硫酸软骨素和含有该寡糖的药物组合物
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摘要
A sugar donor having a glucuronic acid or iduronic acid derivative at the reducing end and in which a leaving group is added to the reducing end hydroxyl group to be glycosylated and the other hydroxyl groups and the carboxyl groups are protected, is subjected to glycosylation reaction with a sugar acceptor having a N-acylgalactosamine derivative at the reducing end and in which the non-reducing end hydroxyl group to be glycosylated is free and the other hydroxyl groups are protected, in the presence of (A-3) a particular promoter. Provided be can a process for preparing an oligoglycosaminoglycon of an intended chain length composed of four or more constituent sugars in highly stereoselectively, high yield and high purity.
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