MODEL ANIMAL OF DISEASE IN CHROMOSOMAL ABERRATION, METHOD FOR PREPARING THE SAME AND METHOD FOR EVALUATING THERAPEUTIC AGENT USING THE SAME

摘要

PPROBLEM TO BE SOLVED: To provide screening of a candidate drug for treating human diseases caused by chromosomal aberration or to provide a true model animal accurately usable for studies on onset mechanisms of the human diseases. PSOLUTION: A non-human animal or a progeny animal thereof has the chromosomal aberration corresponding to the human chromosomal aberration related to the human diseases which are duplications in the human chromosome 15 q11-13. A mouse or a progeny animal thereof has chromosomal duplications in a murine chromosomal syntenic region, especially between Mkrn gene and Herc gene. PCOPYRIGHT: (C)2007,JPO&INPIT