Drug administration for nano-suspension with increased dissolution rate and saturation solubility

摘要

(57) Abstract The system whose saturation solubility (Cs) is high considerably can by manufacturing the nano- suspensoid of the medicine. Therefore, it is possible to raise the saturation solubility of the medicine whose organism utilization characteristic is low. You can obtain the melting speed which is higher than the melting speed which is obtained with this addition increase of saturation solubility, by the simple increase of the surface area of the medicine. Quite stability you can obtain nano- suspensoid very low with the surface active agent of density and using the stabilizer. It is possible to manufacture the nano- suspensoid which does not contain boundary activity. The nano- suspensoid whose contents of the particle which possesses the grain size of the micrometer range are very few can be produced on a large scale without impairing the advantage making use of cavitation method. Because the powdered medicine particle is thought, that the gap of almost 25 millimicrons is blocked, until recently manufacturing the nano- suspensoid which is by cavitation method was made impossible. It flows from the viewpoint of optimum stability and the surface active agent non- containing formulation and, it is possible to manufacture nano- suspensoid with shearing or the shocking action which uses the dispersed device.