Bordetellasp for use in immunological diagnosis and monitoring. Immune monitoring methods, as well as immune monitoring kit or diagnosis including the recombinant adenylate cyclase or diagnostic methods using recombinant adenylate cyclase, the recombinant adenylate cyclase

摘要

For example, immune monitoring and diagnostic testing using the Bordetella pertussis CyaA that has been genetically detoxified as a delivery system, any effective immune response, such as the immune response generated by vaccination or non-infectious diseases and infectious also to track is. Fused to CyaA or a fragment thereof, or T cells stimulated by the previously given antigen can be restimulated in vitro by the same antigen that is chemically coupled. The present invention, M. and an immune monitoring or diagnostic tests of tuberculosis by providing a delivery system capable of non-human animal cells and human cells, be delivered, for example, to a cell, a cow, a CFP-10 and tuberculosis immunodominant protein ESAT-6. In addition, cancer, for example, a fusion protein with the cancer antigens and CyaA is also provided as an immune system monitoring and diagnostic test for melanoma.