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Sigma-1 receptor ligand with acetylcholinesterase inhibitory properties
Sigma-1 receptor ligand with acetylcholinesterase inhibitory properties
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机译:具有乙酰胆碱酯酶抑制特性的Sigma-1受体配体
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摘要
A novel compound and method for preventing or treating neurodegenerative diseases by inhibiting acetylcholinesterase and binding the sigma-1 receptor are disclosed. Dimethylcarbamic acid 2,3-bis-dimethylcarbamoyloxy-6-[4-(4-ethyl-piperazin-yl)-butyryl]-phenyl ester and its derivatives represent a novel therapeutic strategy against beta-amyloid peptide induced neurotoxicity, in inhibiting acetylcholinesterase, in improving cholinergic transmission, in binding the sigma-l receptor, and in releasing a metabolite that is active both as a sigma-1 receptor ligand and an antioxidant.
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