-N- Amino acid carboxy anhydride having a substituent at the nitrogen atom

摘要

PROBLEM TO BE SOLVED: To provide a new amino acid-N-carboxyanhydride with an N-acyl substituent on the nitrogen atom as an important intermediate considered as highly useful in various fields including medicinal and agrochemical fields and having been unavailable by conventional production techniques, to provide a method for producing the amino acid-N-carboxyanhydride, and to provide a method for producing an inexpensive diamide compound in few steps by the use of the above new compound without causing problems such as racemization. SOLUTION: This new amino acid-N-carboxyanhydride of formula (1) is highly reactive with a nucleophilic reagent such as a free amino acid, an alcohol or anion and serves as an intermediate useful for producing in high yield amino acid derivatives, optically active compounds, peptides, polypeptides, etc., each useful in various fields including medicinal and agrochemical fields. The 2nd objective method for producing the above new compound, and the other objective method for producing a diamide involving using the new compound of formula (1) and an amine derivative of formula (7), are also provided, respectively.