Improved therapeutic composition comprising a bactericidal / permeability enhancing protein (BPI) protein product

摘要

Improved therapeutic compositions having enhanced anti-microbial activity comprising a bactericidal/permeability-increasing (BPI) protein product and a bactericidal-activity enhancing polyoxyethylene block copolymer surfactant (poloxamer surfactant) or a bacterial and fungal growth-inhibiting enhancing poloxamer surfactant, optionally with EDTA, and methods for treating bacterial infection by administering such compositions, alone or concurrently with antibiotics.