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Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
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机译:吡咯并苯二氮杂为合成二聚细胞毒性吡咯并苯二氮杂的关键中间体
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摘要
Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R2 and R3 are independently selected from —H, ═O, ═CH2, —CN, —R, OR, halo, ═CH—R, O—SO2—R, CO2R and COR; R10 is a carbamate-based nitrogen protecting group; and R11 is an oxygen protecting group. 展开▼
机译:化合物和式(Ia)或(Ib)化合物的合成方法:及其盐,溶剂化物和化学保护形式,其中虚线表示在C1和C2或C2和C3之间任选存在双键; R 2 Sup>和R 3 Sup>分别选自-H,═O,═CH 2 Sub>,-CN,-R,OR,卤素, ═CH-R,O-SO 2 Sub> -R,CO 2 Sub> R和COR; R 10 Sup>是一个基于氨基甲酸酯的氮保护基团; R 11 Sup>是氧保护基。 <图像alt =“嵌入式图像” file =“ US20070191309A1-20070816-C00001.GIF” he =“ 75.95mm” imgContent =“ chem” imgFormat =“ GIF” wi =“ 69.85mm“ /> 化学>
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