Alpha-1-phosphorylated-2-deoxy-2-fluoroarabinoside and process for producing 2'-deoxy-2'-fluoro-beta-d-arabinonucleoside

摘要

A method for producing 2′-deoxy-2′-fluoro-β-D-arabinonucleoside represented by formula (II): [F3] (wherein B represents a base), in particular, 2′-deoxy-2′-fluoro-β-D-arabinopurinenucleoside, which method comprises causing a nucleoside phosphorylase to act on α-1-phosphorylated-2-deoxy-2-fluoroarabinoside represented by formula (I): [F1] or a mixture of α- and β-isomers of 1-phosphorylated-2-deoxy-2-fluoroarabinoside represented by formula (V′): [F2] and on a base. The compound can be produced at high yield and in a convenient and highly stereoselective manner.