Method for the evaluation of the functional status of the growth factor receptor protein expressed in malignant tumors

摘要

A novel examination method for accurately evaluating the effectiveness of treatment with an anticancer drug for the administration of the anticancer drug targeting a tumor-associated factor receptor is provided. In order to evaluate the effectiveness of trastuzumab (Herceptin™) of an anticancer drug, it was found to be meaningful to examine the expression of MUC4, that is, a substance which interacts with HER2/c-erbB-2 belonging to the epidermal growth factor receptor family on the surface of and/or within the cell membrane. From this fact, in order to treat various cancers with an anticancer drug targeting the tumor-associated factor receptors, it was found to be meaningful to detect previously the expression of intracellular ligands against the receptors. The finding completes the present invention.