Method of treating cancer and neuropathic complications induced by chemotherapeutic agents using selective Bradykinin B1 receptor antagonists

摘要

The present invention relates to a method for the use of a bradykinin B1 receptor antagonist of formula I: X—CO-Aaa₀-Aaa₁-Aaa₂-Aaa₃-Gly-α(Me)Phe-Ser-D-βNal-Aaa₈-OH  (I)or a pharmaceutically acceptable salt or hydrate thereof wherein: X is C_nH_2n+1 or C_iH_2i—C₆H₅, where n is an integer from 1 to 3, and i is an integer from 0 to 3; Aaa₀ is Lys, Orn or Cit; Aaa₁ is Arg or Cit, and preferably Arg; Aaa₂ is Oic, Hyp or Pro, and preferably Oic; Aaa₃ is Pro or Oic, and preferably Pro; and Aaa₈ is Ile, Leu, Nle, and preferably Ile, for the treatment of metastases, cancers and/or chemotherapy-induced neuropathies, comprising the administration of said compound to a patient in need of such treatment. The present invention also relates to compositions containing such antagonists and the uses thereof.