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Process for the preparation of 1,1,3,3-tetraalkylisoindoline starting from n-benzylphthalimide
Process for the preparation of 1,1,3,3-tetraalkylisoindoline starting from n-benzylphthalimide
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机译:由正苄基邻苯二甲酰亚胺制备1,1,3,3-四烷基异吲哚啉的方法
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摘要
Process for the preparation of 1,1,3,3-tetra-alkyl derivatives of isoindoline which comprises the transformation of N-benzylphthalimide into N-benzyl-1,1,3,3-tetra-alkylisoindoline by means of treatment with a Grignard reagent prepared in methyl-tert-butyl ether starting from magnesium and an alkyl halide and subjecting the intermediate thus obtained to a hydrogenolysis reaction in the presence of hydrogen and a catalyst based on supported palladium.
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