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Decorin proteoglycan inhibitor of fibrinogen blood clotting
Decorin proteoglycan inhibitor of fibrinogen blood clotting
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机译:纤维蛋白原凝血的Decorin蛋白聚糖抑制剂
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摘要
The present invention provides compositions and methods of inhibiting fibrin(ogen) clot formation by utilizing decorin proteoglycan as an anticoagulating and antithrombotic agent. The decorin proteoglycan comprises a decorin core protein or a fragment thereof covalently linked to a galactosaminoglycan polysaccharide. The decorin core protein acts as an anticoagulant and as a carrier for the delivery of an antithrombotic galactosaminoglycan to fibrinogen. Fibrin clotting is inhibited by the decorin proteoglycan in a concentration-dependent fashion.
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