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6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adpribose) polymerase inhibitors

机译：6-链烯基和6-苯基烷基取代的2-喹啉酮和2-喹喔啉酮作为聚（阿布波糖）聚合酶抑制剂

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摘要

The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors embedded image

wherein n, R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R^e, R^dand X have defined meanings.

机译：本发明提供式（I）的化合物和式（VII-a）的化合物，以及包含所述化合物的药物组合物及其作为PARP抑制剂的用途 <图像alt =“嵌入式图像” file =“ US20070072842A1-20070329-C00001.GIF” he =“ 66.12mm” imgContent =“ chem” imgFormat =“ GIF” wi =“ 69.93mm“ /> 其中n，R ^{1 ，R ^{2 ，R ^{3 ，R ^{4 ，R ^{5 ，R ^{6 ，R ^{7 ，R ^{e ，R ^{d 和X具有定义的含义。}}}}}}}}}

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公开/公告号US2007072842A1

专利类型
公开/公告日2007-03-29

原文格式PDF
申请/专利权人 MABIRE JEAN-PIERRE DOMINIQUE;JEROME EMILE GEORGES GUILLEMONT;JACOBUS ALPHONSUS JOSEPHUS VAN DUN;MARIA VICTORINA FRANCISCA SOMERS;WALTER BOUDEWIJN LEOPOLD WOUTERS;
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申请/专利号US20040595891
发明设计人 MABIRE JEAN-PIERRE DOMINIQUE;JEROME EMILE GEORGES GUILLEMONT;JACOBUS ALPHONSUS JOSEPHUS VAN DUN;MARIA VICTORINA FRANCISCA SOMERS;WALTER BOUDEWIJN LEOPOLD WOUTERS;
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申请日2004-11-18
分类号A61K31/55;A61K31/5377;A61K31/498;A61K31/4747;A61K31/4709;C07D403/02;C07D413/02;
国家 US
入库时间 2022-08-21 21:03:15

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