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2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases

机译:2-杂芳基-咪唑并三嗪酮及其在治疗炎症或免疫疾病中的用途

摘要

embedded image The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R1 denotes 5- to 10-membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C1-C4)-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3- to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C1-C6)-aldyl, (C1-C6)-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C2-C10)-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C1-C6)-alkoxy, hydroxy, halogen, 3- to 10-membered carbocyclyl and oxo.
机译: “嵌入式图像” 本发明涉及2-杂芳基-咪唑并三嗪酮,其制备方法及其在药物中的用途,尤其是在药物中。用于治疗和/或预防炎症过程和/或免疫疾病。本发明涉及通式(I)的化合物,其中R Sup 1表示5至10元杂芳基,其任选地被选自卤素的相同或不同残基取代, (C 1 -C 4 )-烷基,三氟甲基,氰基,硝基和三氟甲氧基表示3至10元碳环或碳键,4至10-杂环基,其中碳环基和杂环基可任选地被选自(C 1 -C 6 )-醛基,(C 1 -C 6 )-醛氧基,羟基,卤素,三氟甲基和氧代,或表示(C 2 -C 10 ) -烷基,其任选地被选自(C 1 -C 6 )-烷氧基,羟基,卤素,3-的相同或不同残基取代10元碳环基和氧代。

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