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Retro-anandamides, high affinity and stability cannabinoid receptor ligands
Retro-anandamides, high affinity and stability cannabinoid receptor ligands
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机译:Retroananamides,高亲和力和稳定性大麻素受体配体
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摘要
Novel retro-anandamides are presented which have high affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and/or greater metabolic stability make these analogs therapeutically useful as medications in individuals and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy, as well as suppression of the immune system, enhancement of appetite and in treatment of certain mental disorders.
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