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Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
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机译:使用内体膜去稳定剂增强SPLP介导的转染的方法
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摘要
The present invention provides novel and surprisingly effective methods for delivering nucleic acids to cells. These methods are based upon the discovery that the presence of endosomal membrane destabilizers (e.g., calcium) leads to a dramatic increase in the transfection efficiency of plasmids formulated as SPLP, or “stabilized plasmid-lipid particles.”
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