Methods, computer systems, and computer program products for segmenting tissue based upon image data representing brain tissue are disclosed. In the method, image data representing brain tissue is reformatted to a predetermined spatial orientation. Spatial statistics relating to spatial features of the represented brain tissue are determined. The represented brain tissue is classified within categories of white matter, gray matter and cerebrospinal fluid. A region of interest in the represented brain tissue classified as cerebrospinal fluid is identified. The represented brain tissue proximate the identified region is segmented using a region-growing technique based on the identified region of interest.
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