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Selective enzymatic esterfication and solvolysis of epimeric vitamin D analog and separation and epimerization of the epimers
Selective enzymatic esterfication and solvolysis of epimeric vitamin D analog and separation and epimerization of the epimers
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机译:异构酶维生素D类似物的选择性酶促酯化和溶剂分解以及异构体的分离和异构化
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摘要
Since the C-24 of the vitamin D derivatives having C-24 hydroxyl branch is a chiral center, there are two epimers, i.e. C-24R hydroxyl and C-24S hydroxyl, that can be found. However, only the diastereomer with C-24S hydroxyl is biologically active. A method for selectively enzymatically esterifying or selectively enzymatically solvolyzing a mixture of epimers of the C-24 hydroxyl vitamin D derivatives is disclosed here. The method can be used to separate these two diastereomers from a mixture of the epimers thereof for purification process. In addition, the method can be used for isomerising the C-24R hydroxyl epimer for further recycling purposes.
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