Piridinureas of Antranilamida as inhibitors of the kinase receptor of vascular endothelial growth factor (VEGF)

摘要

This is piridinureas of Antranilamida as inhibitors of the kinase receptor of vascular endothelial growth factor (VEGF), its production and use as pharmaceutical Agents for treating Diseases triggered by persistent angiogenesis.Claim 1, characterized because it responds to a compound of formula (1) where X is CH or N; W is H or F,, e and Q, independently of one another, or are CH N, where the Ring contains only a maximum of Two N Atoms; r1 is aryl or heteroaryl, which can be Optionally substituted and One or more places, so the same or different, with Halogen, alkyl hydroxyl C1 -, 12 -,Alquenilo C1 - C2 - 6 -, 12 -, Halo - C1 - 6 alkoxyl, alkyl, or so2r6 =, -, - OR5 sor4 cor6, -, -, - or - co2r6 nr7r8, where C1 - 12 can be substituted with alkyl - or - OR5 nr7r8, bearing in mind that, when R2 and R3 are both - CH3, R1 is not none of the compounds of formulas (2); R2 and R3, independientement And one another, are replaced with C1 - 12 - OR5 optionally alkyl; R4 is C1 - 12 alkyl,C3 - 8 - cycloalkyl, aryl or heteroaryl; R5 C1 - 12 is H, alkyl, cycloalkyl or C3 - 8 - 6 - Halo - C1 - R6 is H, alkyl; C1 - C3 - 8 12 alkyl, cycloalkyl -, Halo - C1 - 6 - alkyl -, aryl or nr7r8; R7 and R8, independently of one another, are so2r6 cor6 h, -, -, aryl, C1 - C3 - 8 cycloalkyl alkyl -, 12 -, Halo - C1 - 12 - alq - or uilo c1-12 alkoxyl,Where C1 - 12 alkyl can be replaced optionally with OR5 - or - N (CH3) 2, or R7 and R8 can also be selected so as to obtain a cycloalkyl Ring D 3 - 8 members, which optionally may contain other hetero ATOMS, and can be optionally substituted by one or more Lu Gares, equally or differently, halogeno, cyano, C1 - 12 - c1-12 alkoxyl alkyl -,Halo - C1 - 6 = alkyl, or OR5 cor6, -, -, - or - so2r6 SR4, sor4; and also tautomeros isomers, Diastereomers, enantiomers, and salts thereof.